Novel wound dressings for controlled release of NSAID
A wound may be defined as an injury to the skin and underlying tissue. Normally it would heal by going through well-characterized healing phases, such as inflammation, granulation, epitheliazation and closure. In a chronic wound, the healing process has become trapped in either of the phases before...
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| Main Authors: | , , , , |
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| Format: | Software Book Chapter |
| Jezik: | English |
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| Sorodne knjige/članki: | Vsebovano v:
Fibrous products in medical and health care |
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| LEADER | 03053naa a2200289 ib4500 | ||
|---|---|---|---|
| 001 | 15146262 | ||
| 003 | SI-MaCOB | ||
| 005 | 20150401000000.0 | ||
| 006 | m|||||q||d|||||||| | ||
| 007 | co|||| | ||
| 008 | 110708s2011 fi |||||q|||||||| ||eng c | ||
| 040 | |a KTFMB |b slv |c SI-MaIIZ |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 080 | |a 677 | ||
| 245 | 1 | 0 | |a Novel wound dressings for controlled release of NSAID |h [Elektronski vir] / |c T. Maver ... [et al.]. |
| 300 | |a 7 str. | ||
| 500 | |a Nasl. pri prispevku. | ||
| 500 | |a Soavtorji še: Z. Peršin, K. Herzič, D.M. Smrke, K. Stana Kleinschek. | ||
| 504 | |a Bibliografija: str. 7. | ||
| 520 | |a A wound may be defined as an injury to the skin and underlying tissue. Normally it would heal by going through well-characterized healing phases, such as inflammation, granulation, epitheliazation and closure. In a chronic wound, the healing process has become trapped in either of the phases before closure. Chronic wounds are characterized by a prolonged inflammation phase, the failure to re-epithelialize and by a defective remodeling of the extracellular matrix. Wounds are often associated with chronic and severe painin the wound. Wound dressings, capable of delivering anti-inflammatory pain-killing agents to the wound bed in a controlled way, offer great potential to increase the quality of life of patients. This is especially the case, when the patients suffer from severe pain, caused by a chronic wound. Delivering non-steroid anti- inflammatory pain-killing drugs (NSAIDs) directlyto the wound and surrounding tissue drastically lowers the risk of systemic side effects, which otherwise often encountered if oral NSAID are used. In our study we evaluate different combinations of base wound dressing materials with a NSAID, to find the most effective delivery system for topicaluse. Wound dressings will be tested in vitro to find the one with the desired release profile. The chosen three base materials (viscose, alginate and PET) already proved to be suitable for preparation of drug delivery systems to the wound, while the chosen incorporated NSAID is something new in the topical treatment of wounds. In vitro release testing will be performed using the Franz diffusion cell, where samples will be collected at different times and the concentrations of the released drug will be measured using UV spectroscopy. Preliminary results show significant differences in the release profiles between different combinations of base materials and NSAIDs. Certain combinations show already great potential for further exploitation in therapeutic use. | ||
| 653 | 0 | |a disinfection |a wound |a regenerated cellulose fibres | |
| 700 | 1 | 2 | |a Maver, Tina. |4 aut |
| 700 | 1 | 2 | |a Peršin, Zdenka. |4 aut |
| 700 | 1 | 2 | |a Herzič, K. |4 aut |
| 700 | 1 | 2 | |a Smrke, Dragica. |4 aut |
| 700 | 1 | 2 | |a Stana-Kleinschek, Karin. |4 aut |
| 773 | 0 | |a International Conference on Fibrous Products in Medical and Health Care (2011 : Tampere, Finland) |t Fibrous products in medical and health care |d Tampere : University of Technology, 2011 |w 15145750 |g 7 str. | |