Chemometrics exploration of phospholipid fatty acids in erythrocyte membranes
The study presented here aims to compare the fatty acid composition and their characteristic profiles derived from erythrocyte phospholipids of patients with different diseases and to test the hypothesis that the changes in their profiles might be relevant to various diseases and metabolic abnormali...
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| Format: | Software Book Chapter |
| Jezik: | English |
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| 007 | co|||| | ||
| 008 | 111027s2011 xo |||||q|||||||| ||eng c | ||
| 040 | |a KTFMB |b slv |c SI-MaIIZ |e ppiak | ||
| 041 | 0 | |a eng |b eng | |
| 080 | |a 577 | ||
| 100 | 1 | |a Brodnjak-Vončina, Darinka. |4 aut | |
| 245 | 0 | 0 | |a Chemometrics exploration of phospholipid fatty acids in erythrocyte membranes |h [Elektronski vir] / |c Darinka Brodnjak Vončina, Zdenka Cencič Kodba, Marjana Novič. |
| 300 | |a Str. 23-28. | ||
| 504 | |a Bibliografija: str. 28. | ||
| 504 | |a Abstract. | ||
| 520 | |a The study presented here aims to compare the fatty acid composition and their characteristic profiles derived from erythrocyte phospholipids of patients with different diseases and to test the hypothesis that the changes in their profiles might be relevant to various diseases and metabolic abnormalities. The study sample consisted of 272 patients, among them 135 with inflammatory bowel disease (60 patients with Crohn disease and 75 patients with other inflammatory bowel diseases), 53 with uterine leiomyoma, 14 with verified absence of uterine leiomyoma, 52 with asthma, 18 with colon adenomas and 70 blood samples without any of mentioned diseases that were used as a control group. A robust and reliable analytical method, additionally improved and optimised, was used for the lipid extraction, separation of lipid classes and isolation of phospholipids by silica solid phase. Plasmalogens act as targets for oxidants and are major lipophilic antioxidants. The resulting fatty acids and plasmalogen linked dimethyl acetals were evaluated by the principal component analysis (PCA) by chemometrics and statistical methods. The study suggests differences in membrane fatty acid profiles in patients with different diseases which might have a potential for diagnostics and population screening for diseases, where fatty acids may play role as biomarkers for diseases. | ||
| 653 | 0 | |a erythrocyte phospholipids |a cell membranes |a fatty acid profiles |a differentiation |a disease states |a gas chromatography |a principal component analysis | |
| 700 | 1 | 2 | |a Cencič-Kodba, Zdenka. |4 aut |
| 700 | 1 | 2 | |a Novič, Marjana. |4 aut |
| 773 | 0 | |a International conference Applied natural sciences (2011 : Trnava) |t Proceedings |d Trnava : University of SS. Cyril and Methodius, 2011 |w 15468822 |z 9788081052668 |g Str. 23-28 | |