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Safety and efficacy of l-leucine produced by fermentation with Escherichia coli NITE BP-02351 for all animal species EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel) : scientific opinion /

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-leucine produced by fermentation with Escherichia coli NITE BP-02351 when used as nutritional additive or as feed flavouring...

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Bibliografske podrobnosti
Main Authors: Bampidis, Vasileios. (Author), Azimonti, Giovanna. (Author), Ramos, Maria de Lourdes da Silva. (Author), Christensen, Henrik. (Author), Dusemund, Birgit. (Author), Kouba, Maryline. (Author), Kos Durjava, Mojca. (Author), López-Alonso, Marta. (Author), López Puente, Secundino. (Author), Marconi, Francesca. (Author), Mayo, Baltasar. (Author), Pechová, Alena. (Author), Petkova, Mariana. (Author), Sanz, Yolanda. (Author), Villa, Roberto Edoardo. (Author), Woutersen, Ruud. (Author), Costa, Lucio G. (Author), Cubadda, Francesco. (Author), Dierick, Noël Albert. (Author), Flachowsky, G. (Author), Glandorf, Boet. (Author), Herman, Lieve. (Author), Mantovani, Alberto. (Author), Saarela, Maria. (Author), Wallace, R. John. (Author), Montserrat, Anguita. (Author), Tarrés-Call, Jordi. (Author), Ramos, Fernando. (Author)
Format: Book Chapter
Jezik:English
Teme:
nutritional additive > leucine > Escherichia coli NITE BP 02351 > amino acid > favouring > sensory additive
krma > krmni dodatki > amino kisline > senzorični dodatki > Escherichia coli NITE BP 02351
Sorodne knjige/članki:Vsebovano v: EFSA journal
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024 7 1 |a 10.2903/j.efsa.2019.5689  |2 doi 
041 0 |a eng  |b eng 
080 |a 66  |2 UDCMRF 2011 
245 1 0 |a Safety and efficacy of l-leucine produced by fermentation with Escherichia coli NITE BP-02351 for all animal species   |h [Elektronski vir] :   |b EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel) : scientific opinion /   |c Vasileios Bampidis ... [et al.].  
256 |a El. prispevek.  
300 |a 19 str. :   |b Tabele. 
500 |a Soavtorji: Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Maryline Kouba, Mojca Kos Durjava, Marta López-Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Lucio Costa, Francesco Cubadda, Noël Dierick, Gerhard Flachowsky, Boet Glandorf, Lieve Herman, Alberto Mantovani, Maria Saarela, Robert John Wallace, Montserrat Anguita, Jordi Tarrés-Call, Fernando Ramos.  
500 |a Nasl. z nasl. zaslona.  
500 |a Opis vira z dne 7. 5. 2019.  
504 |a Abstract.  
504 |a Bibliografija: str. 14.  
520 |a Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-leucine produced by fermentation with Escherichia coli NITE BP-02351 when used as nutritional additive or as feed flavouring compound in feed and water for drinking for all animal species. The product under assessment is l-leucine produced by fermentation with a genetically modified strain of E. coli (NITE BP-02351). The production strain and its recombinant DNA were not detected in the final products. l-Leucine, manufactured by fermentation with E. coli NITE BP-02351, does not give rise to any safety concern to the production strain. The use of l-leucine produced with E. coli NITE BP-02351 is safe for the target species when used to supplement the diet in appropriate amounts. It is safe at the proposed use level of 25 mg/kg when used as flavouring compound for all animal species. The use of l-leucine produced by fermentation with E. coli NITE BP-02351 in animal nutrition raises no safety concerns for consumers of animal products. The additive is not irritating to the skin or eyes and is not a skin sensitiser. There is a risk for persons handling the additive from the exposure to endotoxins by inhalation. The use of l-leucine produced by E. coli NITE BP-02351 as feed additive does not represent a risk to the environment. The additive l-leucine produced by E. coli NITE BP-02351 is regarded as an effective source of the amino acid l%leucine when used as nutritional additive. For the supplemental l-leucine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen. It is also considered efficacious as feed flavouring compound under the proposed conditions of use. 
653 0 |a nutritional additive  |a leucine  |a Escherichia coli NITE BP 02351  |a amino acid  |a favouring  |a sensory additive 
653 0 |a krma  |a krmni dodatki  |a amino kisline  |a senzorični dodatki  |a Escherichia coli NITE BP 02351 
700 1 |a Bampidis, Vasileios.   |4 aut  |0 (SI-MaCOB)275616355 
700 1 |a Azimonti, Giovanna.   |4 aut  |0 (SI-MaCOB)116685411 
700 1 |a Ramos, Maria de Lourdes da Silva.   |4 aut  |0 (SI-MaCOB)275617123 
700 1 |a Christensen, Henrik.   |4 aut  |0 (SI-MaCOB)228453987 
700 1 |a Dusemund, Birgit.   |4 aut  |0 (SI-MaCOB)326204003 
700 1 |a Kouba, Maryline.   |4 aut  |0 (SI-MaCOB)275619427 
700 1 |a Kos Durjava, Mojca.   |4 aut  |0 (SI-MaCOB)5123683 
700 1 |a López-Alonso, Marta.   |4 aut  |0 (SI-MaCOB)275620195 
700 1 |a López Puente, Secundino.   |4 aut  |0 (SI-MaCOB)326220387 
700 1 |a Marconi, Francesca.   |4 aut  |0 (SI-MaCOB)326205027 
700 1 |a Mayo, Baltasar.   |4 aut  |0 (SI-MaCOB)150067299 
700 1 |a Pechová, Alena.   |4 aut  |0 (SI-MaCOB)326206819 
700 1 |a Petkova, Mariana.   |4 aut  |0 (SI-MaCOB)326207843 
700 1 |a Sanz, Yolanda.   |4 aut  |0 (SI-MaCOB)326224227 
700 1 |a Villa, Roberto Edoardo.   |4 aut  |0 (SI-MaCOB)275623523 
700 1 |a Woutersen, Ruud.   |4 aut  |0 (SI-MaCOB)326226275 
700 1 |a Costa, Lucio G.   |4 aut  |0 (SI-MaCOB)303561827 
700 1 |a Cubadda, Francesco.   |4 aut  |0 (SI-MaCOB)326702435 
700 1 |a Dierick, Noël Albert.   |4 aut  |0 (SI-MaCOB)326276195 
700 1 |a Flachowsky, G.   |4 aut  |0 (SI-MaCOB)56471139 
700 1 |a Glandorf, Boet.   |4 aut  |0 (SI-MaCOB)326276451 
700 1 |a Herman, Lieve.   |4 aut  |0 (SI-MaCOB)17306723 
700 1 |a Mantovani, Alberto.   |4 aut  |0 (SI-MaCOB)275620707 
700 1 |a Saarela, Maria.   |4 aut  |0 (SI-MaCOB)18740323 
700 1 |a Wallace, R. John.   |4 aut  |0 (SI-MaCOB)248535139 
700 1 |a Montserrat, Anguita.   |4 aut  |0 (SI-MaCOB)326292323 
700 1 |a Tarrés-Call, Jordi.   |4 aut  |0 (SI-MaCOB)326270819 
700 1 |a Ramos, Fernando.   |4 aut  |0 (SI-MaCOB)275621475 
773 0 |t EFSA journal  |d [Parma] : European Food Safety Authority, 2003-  |x 1831-4732  |g 5689, Vol. 17, Iss. 5 (May. 2019), 19 str. 
040 |a UKM  |b slv  |c SI-MaIIZ  |e ppiak 

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